[Cryoglobulinemic neuropathy. A Clinical and neurophysiologic study of 13 cases]

Thirteen patients with essential mixed cryoglobulinemia and neuropathy were studied and followed up clinically and neurophysiologically during last nine years. All these patients had a mild distal, symmetrical motor sensory neuropathy. Few patients had a mononeuropathy. Three patients developed an acute severe tetraparesis due to overlapping mononeuritis multiplex. Neurophysiological study and nerve biopsy were indicative of axonal neuropathy. We discuss the pathogenesis of this neuropathy and the therapeutical approach.