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The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...

Functional Brain Systems: Reticular Formation

Functional Brain Systems: Reticular Formation

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Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

Comparison between RL and RC circuits

Comparison between RL and RC circuits

An RC circuit consists of resistance and capacitance, while in an RL circuit, capacitance is replaced by an inductor. RL and RC circuits are first-order differential circuits that store energy. An RC circuit stores energy in the electric field, while an RL circuit stores energy in the magnetic field. When connected to a battery, an RC circuit charges the capacitor, causing the current to decrease from maximum to zero upon being fully charged. This increases the voltage across the capacitor from...

The Scientific Method

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Parallel Resonance

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The parallel RLC circuit is an arrangement where the resistor (R), inductor (L), and capacitor (C) are all connected to the same nodes and, as a result, share the same voltage across them. The parallel RLC circuit is analyzed in terms of admittance (Y), which reflects the ease with which current can flow. The admittance is given by:

The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...

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Related Experiment Video

Updated: Jun 21, 2026

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Published on: July 26, 2019

Ras and the FAK paradox.

Marc A Antonyak¹, Richard A Cerione

¹Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.

|August 4, 2009

Summary

Oncogenic Ras negatively regulates Focal Adhesion Kinase (FAK), impacting cancer cell movement and invasion. This discovery reveals a novel mechanism in cancer progression.

Area of Science:

Molecular biology
Cancer research
Cell signaling

Background:

Focal Adhesion Kinase (FAK) is a key regulator of cell migration and invasion.
Oncogenic Ras proteins are frequently mutated in human cancers, driving tumor growth and metastasis.

Discussion:

The study by Zheng et al. (2009) reveals an unpredicted negative regulatory role of oncogenic Ras on FAK activity.
This interaction challenges previous assumptions about Ras signaling in cancer cell motility.

Key Insights:

Oncogenic Ras directly inhibits FAK, a critical enzyme for cell adhesion and movement.
This negative regulation by Ras has significant implications for understanding and targeting cancer cell invasion.

Outlook:

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Further research into the precise molecular mechanisms of Ras-mediated FAK inhibition could unveil new therapeutic strategies.

Investigating this pathway may lead to novel approaches for inhibiting cancer metastasis.