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Evidence for phosphatidylinositol anchorage of opioid binding proteins in rat brain
F Trovero1, J Glowinski, M Lévy
1INSERM U.114, Chaire de Neuropharmacologie, Collège de France, Paris.
Brain Research
|December 24, 1990
Abstract:
Treatment of rat brain sections and of thalamic and striatal membranes with phosphatidylinositol phospholipase C (PIPLC), an enzyme known to hydrolyse only phosphatidylinositol and its derivatives, significantly alters the specific binding of mu- and delta-opioid ligands on their receptors. These results suggest that some opioid binding proteins are membrane-anchored by a glycosylphosphatidylinositol (GPI) linkage.