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[Propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy]

Dinghua Xiao1, Fen Wang, Xiaoyan Wang

  • 1Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|August 4, 2009
PubMed

Insights

Propofol and midazolam intravenous anesthesia is safe and effective for pediatric upper gastrointestinal endoscopy. This combination provides good sedation for children undergoing endoscopic procedures.

Area of Science:

  • Anesthesiology
  • Gastroenterology
  • Pediatrics

Background:

  • Pediatric upper gastrointestinal endoscopy requires effective sedation.
  • Propofol and midazolam are commonly used anesthetic agents.

Purpose of the Study:

  • To evaluate the safety and efficacy of combined propofol and midazolam intravenous anesthesia in pediatric patients undergoing upper gastrointestinal endoscopy.

Main Methods:

  • 497 patients (children 2-14 years, adults 18-65 years) received midazolam (0.02-0.03 mg/kg) and propofol (0.6-0.7 mg/s) intravenously.
  • Sedation quality, patient response, recovery time, and physiological parameters (SpO2, R, HR, BP) were assessed.

Main Results:

  • Both groups achieved good sedation.
  • Pediatric patients showed a lower rate of pro-endoscopy cooperation (42% vs. 100%) and longer recovery times (17.5 min vs. 9.5 min).
  • Higher incidence of restlessness and increased propofol dosage per kg were observed in children.

Conclusions:

  • Combined propofol and midazolam intravenous anesthesia is a safe and effective option for pediatric upper gastrointestinal endoscopy.
  • While effective, pediatric patients may require closer monitoring due to longer recovery times and increased restlessness.
Abstract

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