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Published on: July 21, 2023
[Effect of hyperbaric oxygen therapy on lumbar intertransverse fusion in rabbits]
Jianhuang Wu1, Jiangnan Zhou, Qiande Liao
1Department of Spinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China. wujianhuang11@126.com
Objective:
To observe the effect of hyperbaric oxygen (HBO) therapy on lumbar intertransverse fusion in rabbits.
Methods:
Twenty-eight healthy adult female rabbits underwent lumbar intertransverse fusion at L( 5-6) with autogenous iliac bone graft. They were randomly assigned into an HBO group and a control group (n=14). Rabbits were killed 6 weeks after the operation for surgical inspection, X-ray, bone density measurement and histologic analysis.
Results:
The fusion rate of the HBO group evaluated by surgical inspection, and radiologic examination in a blind fashion significantly increased compared with that of the control group (P<0.05). Qualitative histologic assessment showed increased bone formation and bone maturity in the HBO group compared with the control group.
Conclusion:
Hyperbaric oxygen therapy could improve the fusion rate of lumbar intertransverse fusion in rabbits.