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A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
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Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation

Marnie E Gelbart1, Erica Larschan, Shouyong Peng

  • 1Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.

Nature Structural & Molecular Biology
|August 4, 2009
PubMed

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Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Heterochromatin

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