Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an ab initio learned model of electron deposition range in deuterium-tritium plasmas through time-dependent density functional theory calculations and machine learning.

Physical review. E·2026
Same author

Targeted transdermal scopolamine delivery over the salivary glands for sialorrhea: Dose-response and systemic safety in rats.

Journal of pharmaceutical sciences·2026
Same author

Neonatal hypoglycemia triggered by maternal ritodrine administration is caused by inhibition of gluconeogenesis in the neonatal liver in rodents.

Biochemical and biophysical research communications·2025
Same author

Greater than 1000-fold Gain in a Free-Electron Laser Driven by a Laser-Plasma Accelerator with High Reliability.

Physical review letters·2025
Same author

Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Drug-drug interaction between trastuzumab emtansine (T-DM1) and orally administered tacrolimus in a patient and in rats.

Drug metabolism and pharmacokinetics·2025

Related Experiment Video

Updated: Jun 21, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)
07:19

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)

Published on: June 28, 2017

High-temporal contrast using low-gain optical parametric amplification.

Rahul C Shah1, Randall P Johnson, Tsutomu Shimada

  • 1Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

Optics Letters
|August 4, 2009
PubMed
Summary
This summary is machine-generated.

Low-gain optical parametric amplification (OPA) enhances laser pulse temporal contrast to a detection limit of 10(-10). This technique restores frequency-doubled pulses to their original wavelength with over 10% efficiency.

More Related Videos

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier
10:17

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier

Published on: July 12, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)
07:19

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)

Published on: June 28, 2017

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier
10:17

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier

Published on: July 12, 2017

Area of Science:

  • Physics
  • Optics
  • Laser Technology

Background:

  • High temporal contrast is crucial for precision laser applications.
  • Existing methods for improving temporal contrast can be complex or inefficient.

Purpose of the Study:

  • To demonstrate low-gain optical parametric amplification (OPA) for enhancing temporal contrast.
  • To achieve a detection-limited temporal contrast of 10(-10).

Main Methods:

  • Utilizing low-gain optical parametric amplification (OPA).
  • Employing 250 microJ, 500 fs pulses at 1053 nm.
  • Frequency doubling of laser pulses followed by restoration via OPA.

Main Results:

  • Achieved a temporal contrast improvement to a detection-limited level of 10(-10).
  • Demonstrated OPA efficiency greater than 10% for restoring pulse wavelength.

Conclusions:

  • Low-gain OPA is an effective method for significantly improving laser pulse temporal contrast.
  • This technique offers a viable solution for applications requiring high temporal purity.