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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jun 21, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Mining biological pathways using WikiPathways web services.

Thomas Kelder1, Alexander R Pico, Kristina Hanspers

  • 1Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.

Plos One
|August 4, 2009
PubMed
Summary
This summary is machine-generated.

WikiPathways now offers programmatic access via a SOAP web service, complementing its website. This enhances biological pathway data utilization and community curation efforts.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Systems Biology

Background:

  • WikiPathways is a collaborative platform for biological pathway data.
  • Current access is primarily through a wiki-style website.

Purpose of the Study:

  • To introduce a SOAP web service for programmatic access to WikiPathways.
  • To complement existing website functionalities.
  • To enable new methods for pathway data utilization and curation.

Main Methods:

  • Development of a SOAP web service interface.
  • Description of the web service's functionalities.
  • Illustration of use cases through detailed discussion.

Main Results:

  • Programmatic access to biological pathways is now available.
  • The web service offers functionalities complementary to the WikiPathways website.
  • New avenues for pathway information utilization are established.

Conclusions:

  • The SOAP web service expands access to WikiPathways data.
  • This facilitates advanced data analysis and integration.
  • It supports and enhances community-driven pathway curation.