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Anal cancer treated with radio-chemotherapy: correlation between length of treatment interruption and outcome
Stefan Janssen1, Jürgen Meier zu Eissen, Gerd Kolbert
1Department of Radiation Oncology, Medical School Hannover, Hannover, Germany. janssen.stefan@mh-hannover.de
Aim:
The purpose of this study was the evaluation of the feasibility and outcome of definitive radio-chemotherapy without split-course technique but with individualised short treatment interruption in anal cancer patients.
Method:
Between 1993 and 2008, 101 patients with anal cancer were treated in our institution with definitive radio-chemotherapy with individualised short treatment interruptions. Treatment was halted independent of dose in case of acute grade 3 toxicities and started again until improvement. Short interruption was defined as completing treatment without exceeding six cumulative treatment days beyond a scheduled plan; otherwise, it was defined as prolonged interruption.
Results:
Median overall treatment time was 47 days corresponding to an interruption of six cumulative treatment days. Fifty-one patients (50%) had treatment interruption of
Conclusions:
Definitive radio-chemotherapy with short individualised treatment interruption shows high local control and colostomy-free survival rates.
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