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Updated: Jun 21, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with idiopathic

Richard M de Jong1, Rene A Tio, Pim van der Harst

  • 1Thoraxcenter, Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. R.M.de.Jong@thorax.umcg.nl

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|August 4, 2009
PubMed

Insights

Positron emission tomography (PET) stress perfusion-metabolism mismatch is common in idiopathic dilated cardiomyopathy (DCM) patients. This mismatch indicates ischemia and is linked to worse clinical outcomes, including hospitalization and mortality.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Idiopathic dilated cardiomyopathy (DCM) patients without coronary artery disease can exhibit regional myocardial perfusion impairment.
  • Positron emission tomography (PET) reveals preserved metabolism alongside perfusion deficits in these patients.

Purpose of the Study:

  • To evaluate the prognostic significance of PET-defined stress perfusion-metabolism mismatch in DCM.
  • To determine the association between PET-mismatch and adverse clinical outcomes in DCM patients.

Main Methods:

  • 24 DCM patients underwent myocardial perfusion and metabolism PET scans.
  • Assessment of "mismatch" between perfusion and glucose uptake.
  • Investigation of the link between mismatch and clinical outcomes (hospitalization, mortality, heart transplantation).

Main Results:

  • PET-mismatch was identified in 66.7% of DCM patients.
  • The presence of mismatch significantly correlated with adverse clinical outcomes (P=0.03).
  • A higher extent of mismatch also showed a significant association with poorer outcomes (P=0.02).

Conclusions:

  • PET stress perfusion-metabolism mismatch is a frequent finding in DCM.
  • This mismatch serves as an indicator of myocardial ischemia.
  • The presence and extent of mismatch are associated with a poorer prognosis in DCM patients.
Abstract

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