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Related Experiment Video

Updated: Jun 21, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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Microfluidic cell sorter with integrated piezoelectric actuator.

Chun H Chen1, Sung Hwan Cho, Frank Tsai

  • 1Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA. chc008@gmail.com

Biomedical Microdevices
|August 4, 2009
PubMed
Summary

This study presents a low-power micro-sorter using piezoelectric actuation for high-speed cell and particle deflection. The device achieves high throughput and precise control for automated sorting applications.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Electrical Engineering

Background:

  • Precise manipulation of single particles and cells is crucial for various applications.
  • Existing micro-sorting technologies face limitations in speed, power consumption, or control precision.

Purpose of the Study:

  • To develop and demonstrate a low-power, low-voltage on-chip micro-sorter capable of high-speed particle and cell deflection.
  • To enable precise, controlled trajectory alteration of micro-objects based on input voltage.
  • To achieve automated, high-throughput sorting using closed-loop control systems.

Main Methods:

  • Utilized a piezoelectrically actuated micro-sorter for on-chip particle and cell manipulation.
  • Employed rhodamine visualization to confirm flow switching at high actuation frequencies (1.7 kHz).

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  • Developed closed-loop sorting with fluorescence detection, real-time signal processing, and field-programmable-gate-array (FPGA) implementation.

    • Main Results:

    • Demonstrated precise control over cell deflection magnitude and waveform via input voltage.
    • Achieved an open-loop throughput of at least 330 E. Coli cells/s.
    • Reported error-free sorting of fluorescent beads with 70% efficiency in preliminary closed-loop tests.
    • Projected potential for >1,000 particles/s throughput with high purity due to fast actuator response and high flow rates.

    Conclusions:

    • The developed micro-sorter offers a low-power, high-speed solution for single particle and cell manipulation.
    • The system demonstrates precise trajectory control and potential for high-throughput automated sorting.
    • This technology holds promise for advancing applications in cell sorting, diagnostics, and micro-particle analysis.