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Related Experiment Video

Updated: Jun 21, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

S100A11: diverse function and pathology corresponding to different target proteins.

Honglin He¹, Jingjing Li, Shunyan Weng

¹Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

Cell Biochemistry and Biophysics

|August 4, 2009

Summary

S100A11 protein, a calcium-binding molecule, plays diverse roles in inflammation and cell growth. It can act as both a tumor suppressor and promoter, influencing cancer cell proliferation.

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Mapping Dysfunctional Protein-Protein Interactions in Disease

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Published on: October 24, 2025

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Published on: July 8, 2025

Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

S100A11 is a member of the S100 protein family, characterized by EF-hand calcium-binding domains.
It exhibits unique characteristics despite sharing common features with other EF-hand calcium-binding proteins.
S100A11 is broadly expressed across tissues and localized in the cytoplasm, nucleus, and cell periphery.

Purpose of the Study:

To systematically describe the biological roles of S100A11.
To elucidate the mechanisms by which S100A11 interacts with target proteins.
To explore the involvement of S100A11 in inflammation, enzyme activity regulation, and cell growth.

Main Methods:

Review and systematic description of existing literature on S100A11.
Analysis of S100A11's interactions with various target proteins.
Investigation of S100A11's conformational changes upon calcium binding.

Main Results:

S100A11 exists as a non-covalent homodimer with an antiparallel conformation.
Calcium binding induces conformational changes, exposing a hydrophobic cleft for target protein interaction.
S100A11 functions as a dual mediator of cell growth, acting as a tumor suppressor or promoter in different cancers.

Conclusions:

S100A11 exhibits diverse biological functions, including roles in inflammation and cell growth regulation.
Its dual role as a tumor suppressor or promoter highlights its complex involvement in cancer.
Further research on S100A11 is crucial for a comprehensive understanding of its biological significance.