Related Experiment Video
Updated: Jun 21, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
Palladium catalysis in the synthesis of medicinal agents
1Merck & Co Inc, PO Box 2000, R801-201, Rahway, NJ 07065, USA. rob_larsen@merck.com
Abstract:
Palladium-catalyzed reactions are having a great impact on the synthesis of medicinal agents due to their ability to form carbon-carbon and carbon-heteroatom bonds effectively. Quite often the palladium-catalyzed step(s) in a synthesis is key to the overall strategy for preparing a drug candidate. The diversity of the coupling processes is being broadened by the availability of new functionalities for the oxidative addition and transmetalation steps. In addition, the development of new ligands, or the application of existing ligands, is playing a large role in expanding the choices of coupling partners. Traditionally, palladium reactions have constructed achiral systems, however, the number of successful asymmetric syntheses with palladium chemistry is growing. This review will cover the variety of coupling reactions that have been applied to drug synthesis, with representative examples highlighted from the recent literature.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
11:16Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
Published on: August 18, 2020
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Heterogeneous Catalysis
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Catalysis
Catalysis