Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

Conus peptides - combinatorial chemistry at a cone snail's pace.

R M Jones1, G Bulaj

  • 1Cognetix Inc, Department of Medicinal Chemistry, Salt Lake City, UT-84108, USA. rjones@cognetix.com

Current Opinion in Drug Discovery & Development
|August 4, 2009
PubMed
Summary

Conotoxins from cone snails show promise as new central nervous system (CNS) therapeutics due to their receptor selectivity. This review focuses on recent advances in synthesizing their complex disulfide bridges.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications.

Scientific reports·2024
Same author

Alanine response to low energy synchrotron x-ray radiation.

Physics in medicine and biology·2023
Same author

Making copper, silver and gold fullerene cages breathe.

Journal of physics. Condensed matter : an Institute of Physics journal·2022
Same author

Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications.

Scientific reports·2021
Same author

Quality and safety taken out of our hands?

Anaesthesia·2021
Same author

Safety, quality and efficiency of intra-operative imaging for treatment decisions in patients with suspected choledocholithiasis without pre-operative magnetic resonance cholangiopancreatography.

Surgical endoscopy·2021

Area of Science:

  • Medicinal Chemistry
  • Neuroscience
  • Peptide Synthesis

Background:

  • Conotoxins are disulfide-rich peptides from cone snail venom.
  • They exhibit high selectivity for specific receptor subtypes.
  • These properties make them promising candidates for novel central nervous system (CNS) therapeutics.

Purpose of the Study:

  • To review recent advancements in conotoxin research.
  • To highlight regioselective strategies for synthesizing disulfide bridges in conotoxins and other constrained peptides.
  • To cover scientific literature from the past two years.

Main Methods:

  • Literature review of scientific papers published in the last two years.
  • Focus on regioselective synthesis strategies for disulfide bridges.

More Related Videos

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

Related Experiment Videos

Last Updated: Jun 21, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

  • Analysis of conotoxins and other small constrained peptides.

    • Main Results:

    • Recent progress in regioselective disulfide bridge formation has been identified.
    • Specific synthetic strategies applicable to conotoxins are discussed.
    • The review consolidates current knowledge on synthesizing these complex peptides.

    Conclusions:

    • Advancements in synthetic strategies are crucial for developing conotoxin-based therapeutics.
    • Regioselective synthesis enables precise control over conotoxin structure and function.
    • Continued research holds potential for new CNS drug development.