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Updated: Jun 21, 2026
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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
Sulfotransferases as targets for therapeutic intervention
1Department of Chemistry, University of California - Berkeley, Berkeley, CA 94720, USA.
Current Opinion in Drug Discovery & Development
|August 4, 2009
Summary
Sulfated biomolecules are key in cellular communication and disease. Inhibiting sulfotransferase enzymes, which add sulfate groups, offers a promising therapeutic strategy for various conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Enzymology
Background:
- Sulfated biomolecules regulate critical cellular functions.
- These molecules play roles in diverse diseases, including inflammation, cancer, and infection.
- Sulfotransferases are enzymes responsible for adding sulfate groups to biomolecules.
Purpose of the Study:
- To review the role of sulfated biomolecules in cellular communication and disease.
- To discuss the importance of sulfotransferase enzymes.
- To explore strategies for inhibiting sulfotransferase activity.
Main Methods:
- Literature review of recent advances in sulfotransferase research.
- Analysis of evidence linking sulfated biomolecules to disease states.
- Discussion of sulfotransferase mechanisms and inhibition approaches.
Main Results:
- Sulfated carbohydrates and proteins are implicated in acute and chronic inflammation.
- These molecules are involved in tumor progression and microbial pathogenesis.
- Sulfotransferase enzymes are viable targets for therapeutic intervention.
Conclusions:
- Sulfated biomolecules are crucial regulators of cellular processes.
- Sulfotransferases represent important targets for drug development.
- Inhibiting sulfotransferase activity holds therapeutic potential for various diseases.
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