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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Related Experiment Video

Updated: Jun 21, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Peptides as tools in drug discovery.

H Grøn1, R Hyde-DeRuyscher

  • 1Karo Bio USA, Durham, NC 27703, USA. hanne.gron@karobio.com

Current Opinion in Drug Discovery & Development
|August 4, 2009
PubMed
Summary

Peptide ligands targeting protein functional sites accelerate drug discovery. This integrated approach streamlines target validation, structure-based design, and high-throughput screening for faster lead identification.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Drug Discovery

Background:

  • The post-genomics era presents both opportunities and challenges in drug discovery.
  • Identifying effective therapeutics necessitates optimized target selection, assay development, screening, and compound follow-up.
  • New tools and techniques are crucial for efficiently advancing potential drug targets through the discovery pipeline.

Purpose of the Study:

  • To review the application of peptide ligands in drug discovery.
  • To demonstrate how peptide ligands can validate target sites, assist structure-based design, and enable high-throughput screening.
  • To present an integrated discovery program paradigm for accelerated target-to-lead progression.

Main Methods:

  • Utilizing peptide ligands to target specific functional sites on candidate proteins.

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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Peptide-based Identification of Functional Motifs and their Binding Partners
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Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

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Last Updated: Jun 21, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

  • Employing peptide ligands for target site validation and structure-based drug design.
  • Developing robust, sensitive high-throughput screening assays using peptide ligands to identify modulators of protein function.

    • Main Results:

    • Peptide ligands facilitate the validation of protein target sites.
    • They aid in structure-based design programs for therapeutic development.
    • Peptide ligands enable the creation of sensitive high-throughput screens for compound identification.

    Conclusions:

    • An integrated drug discovery program combining peptide ligands with other methods offers a new paradigm.
    • This approach allows for rapid, parallel progression of multiple targets from initial choice to lead identification.
    • Peptide ligands are versatile tools for enhancing efficiency and success in modern drug discovery.