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Measles control--can measles virus inhibitors make a difference?

Richard K Plemper1, James P Snyder

  • 1Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA. rplempe@emory.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|August 4, 2009
PubMed

Insights

Measles virus (MV) infection causes significant global illness and death. This review explores how measles antivirals could complement vaccines to control measles and aid eradication efforts.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Measles virus (MV) infection is a leading cause of global morbidity and mortality.
  • The Measles Initiative (launched 2001) aimed to interrupt MV transmission and assess eradication feasibility.
  • Significant mortality reduction (74%) achieved 2000-2007, but measles cases surged in 2008 in Europe and the US.

Purpose of the Study:

  • To review the potential of measles antivirals to augment vaccination strategies.
  • To discuss how antivirals can strengthen global measles control and eradication efforts.
  • To examine the role of antivirals in post-exposure prophylaxis, case management, and complication amelioration.

Main Methods:

  • Literature review of existing studies on measles virus infection and control.
  • Analysis of the limitations of current live-attenuated measles vaccines.
  • Exploration of potential therapeutic applications of measles antivirals.

Main Results:

  • Measles mortality decreased significantly due to vaccination initiatives.
  • A resurgence of measles cases occurred in 2008, highlighting ongoing challenges.
  • Live-attenuated vaccines have limitations, necessitating alternative or complementary strategies.

Conclusions:

  • Measles antivirals offer a promising avenue to enhance vaccination efficacy.
  • Antivirals could play a crucial role in preventing infection post-exposure and improving patient outcomes.
  • The development and integration of measles antivirals are vital for strengthening global measles control and potentially achieving eradication.

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