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Updated: Jun 21, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
Published on: June 15, 2017
Transgenic and targeted mutant mice in drug discovery
1ETH and University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. rudolph@pharma.unizh.ch
Abstract:
In the process of drug discovery, different classes of genetically-modified animals are valuable tools for the identification of drug targets, distinction of target isoforms, differentiation of signaling pathways, generation of disease models and toxicological testing. The analysis is refined by methodologies which permit the inducible regulation of gene expression in a time- and tissue-specific manner. Finally, multiplexing techniques and knockout embryonic stem (ES) cell libraries will help to link DNA sequence information to biological function.
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