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Related Concept Videos

Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Inductive Effects on Chemical Shift: Overview01:27

Inductive Effects on Chemical Shift: Overview

The protons in unsubstituted alkanes are strongly shielded with chemical shifts below 1.8 ppm. Methine, methylene, and methyl protons appear at approximately 1.7, 1.2 and 0.7 ppm, while the proton signal from methane appears at 0.23 ppm. An electronegative substituent, such as chlorine, withdraws the electron density from the protons, increasing their chemical shift. Progressive substitution of the hydrogens in methane by chlorine shifts the proton signals increasingly downfield, to 3.05 ppm in...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

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Related Experiment Video

Updated: Jun 21, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Role of the Internet in chemoinformatics: recent developments.

O F Güner1, O Casher

  • 1Molecular Simulations Inc, San Diego, CA 92121, USA. osman@msi.com

Current Opinion in Drug Discovery & Development
|August 4, 2009
PubMed
Summary

The World Wide Web and web browsers are revolutionizing scientific research by providing integrated access to information. This review focuses on cheminformatics resources and web-based tools for accessing chemical data online and on intranets.

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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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Last Updated: Jun 21, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
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Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

Area of Science:

  • Cheminformatics
  • Scientific Information Management
  • Web Technologies

Background:

  • The World Wide Web has become integral to scientific research, facilitating access to information.
  • Corporate intranets are now key infrastructures for disseminating proprietary data and enabling research tasks.
  • Web browsers serve as a unified interface for accessing diverse data sources and applications.

Purpose of the Study:

  • To review chemical information resources available on the Internet.
  • To highlight updates on web-based tools for accessing and utilizing chemical information.
  • To focus specifically on cheminformatics within the broader context of web-based scientific information.

Main Methods:

  • Literature review of internet-based chemical information resources.
  • Analysis of web-based tools for cheminformatics applications.
  • Examination of intranet functionalities for accessing proprietary chemical data.

Main Results:

  • The internet offers a vast array of cheminformatics resources.
  • Web-based tools are increasingly sophisticated for chemical data searching and analysis.
  • Intranets provide efficient access to internal chemical databases and computational tools.

Conclusions:

  • The web has fundamentally altered scientific workflows, enhancing productivity and information integration.
  • Cheminformatics is significantly benefiting from web technologies for data access and analysis.
  • Effective utilization of web resources and tools is essential for modern scientific research.