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Updated: Jun 21, 2026

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Recent advances in traceless linkers
1The RW Johnson Pharmaceutical Research Institute, Drug Discovery Division, Spring House, PA 19477, USA. areitz@prius.jnj.com
Abstract:
The use of solid-phase organic synthesis for the preparation of small molecule compound libraries has been the driving force behind the development of new linkers and reaction technologies. Traceless linkers afford targets in which it is not readily apparent where the original point of attachment to the solid support had been. In many cases the site of linker attachment has been replaced with a hydrogen atom. This brief review summarizes some of the advances during the past several years involving traceless linkers in solid-phase organic synthesis.
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