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Updated: Jun 21, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Developments in solution-phase combinatorial chemistry
1ChiroChem Discovery Services LLC, CombiChem Inc, San Diego, CA 92121, USA. msuto@combichem.com
Abstract:
The use of solution-phase parallel synthesis as a means of producing libraries of compounds for lead discovery and optimization has increased steadily. More emphasis has been placed on the development of techniques that are applicable across a range of structures and chemistries. In addition, the techniques have been developed with a medicinal chemistry focus and therefore, can be used by a wide range of chemists in standard laboratory settings. This review highlights some of the developments over the last 12 to 18 months, including the use of multi-component reactions and high-throughput purification. New chemistry that may be applicable to parallel synthesis, useful scavenging techniques, and the combination of several polymer-bound reagents or applications.
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