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ACTH(1-24) stimulates the migration of human monocytes in vitro
S Genedani1, M Bernardi, M G Baldini
1Institute of Pharmacology, University of Modena, Italy.
Peptides
|November 1, 1990
Abstract:
In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.