Related Experiment Video
Updated: Jun 21, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Emerging drugs for prostate cancer
Kashif Siddiqui1, Laurence H Klotz
1University of Toronto, Sunnybrook Health Sciences Centre, Division of Urology, 2075 Bayview Ave. #MG408 Toronto, Ontario M4N 3M5, Canada.
Expert Opinion on Emerging Drugs
|August 5, 2009
Summary
New treatments for castrate-resistant prostate cancer are emerging. Research reviews promising drugs targeting androgen deprivation, specific pathways, and cell cycles to combat prostate cancer mortality.
Area of Science:
- Oncology
- Pharmacology
Background:
- Prostate cancer mortality is often linked to castrate-resistant disease.
- Current treatment strategies require improvement for advanced prostate cancer.
Purpose of the Study:
- To review emerging therapeutic approaches for castrate-resistant prostate cancer.
- To evaluate the rationale, biologic activity, and therapeutic results of novel agents.
Main Methods:
- Literature review of current and investigational treatments.
- Analysis of drugs targeting androgen deprivation, receptor, and synthesis.
- Examination of agents targeting specific signaling pathways.
- Review of immunologic, antioxidant, and cell cycle inhibitor therapies.
Main Results:
- Multiple promising drug classes are under investigation.
- Emerging therapies include LHRH antagonists, novel chemotherapy, immunotherapies, and targeted agents.
- Targeted drugs include tyrosine kinase inhibitors, angiogenesis inhibitors, endothelin antagonists, and matrix metalloproteinase inhibitors.
Conclusions:
- Several promising therapeutic avenues are being explored for castrate-resistant prostate cancer.
- These novel agents offer potential improvements in managing advanced prostate cancer.
- Further research is needed to establish the efficacy and safety of these emerging drugs.
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