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Published on: June 4, 2017
[Results of skin prick test in 908 children with asthma]
Yue Wang1, Xuan Zhang, Chao Wang
1Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325027, China. lmrjohn@163.com
Insights
Skin prick testing revealed a high prevalence of allergies in children with asthma, with inhaled allergens like dust mites being most common. These findings aid in asthma treatment strategies.
Area of Science:
- Allergology
- Pediatric Pulmonology
- Immunology
Context:
- Asthma is a common chronic respiratory disease in children.
- Identifying specific allergens is crucial for effective asthma management.
- Skin prick testing (SPT) is a standard diagnostic tool for allergic diseases.
Purpose:
- To determine the prevalence and types of allergic sensitization in a cohort of 908 children diagnosed with asthma.
- To provide reference data for the etiological diagnosis and targeted treatment of pediatric asthma.
Summary:
- A high positive rate (77.4%) was observed in SPT among children with asthma.
- Inhaled allergens, particularly Dermatophagoides culinae (72.4%) and house dust mites (74.7%), were highly prevalent.
- Common food allergens included shrimp (22.9%), tuna (7.3%), and mussels (6.7%).
- Allergen sensitization rates increased with age, suggesting a dynamic relationship between age and allergic responses in asthmatic children.
Impact:
- The study highlights the significant role of allergic sensitization in pediatric asthma.
- Findings can inform epidemiological surveys and guide the development of specific immunotherapy protocols for asthma.
- Results provide valuable insights for clinicians managing pediatric asthma patients.
Objective:
To report the results of skin prick test in 908 children with asthma in order to provide references for treatment of asthma.
Methods:
Skin prick test was performed using ALK-Abell's inhaled prick reagents and the German Merck company's food prick reagents. Histamine was used for positive control, and normal saline, for negative control.
Results:
Skin prick test showed positive in 703 cases (77.4%). The positive rates of inhaled and food allergens were 76.9% and 37.1%, respectively. Dermatophagoides culinae and house dust mite were two common inhaled allergens (72.4% and 74.7% respectively). Shrimp was the most common food allergen (22.9%), followed by tuna (7.3%) and mussels (6.7%). The strongest response of skin prick test was usually caused by dermatophagoides culinae (64.0%) and house dust mite (66.4%), followed by mould 1 (7.1%). The positive rate of inhaled and food allergens increased with increasing age (p<0.05).
Conclusions:
The positive rate of skin prick test in the 908 children with asthma was higher. These results of this study may be useful in an epidemiological survey and specific immunotherapy of asthma.
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Asthma III: Clinical Manifestations
Asthma I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-I: Introduction
Allergic Reactions: Anaphylaxis

