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4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase

M P Heyes1, B Hutto, S P Markey

  • 1Laboratory of Neurophysiology, Building 10, Room 3D40 National Institute of Mental Health, Bethesda, MD 20892 USA.

Neurochemistry International
|August 5, 2009
PubMed
Summary

4-chloro-3-hydroxyanthranilic acid inhibits 3-hydroxyanthranilic acid oxidase in the brain. This finding is significant because quinolinic acid, a neurotoxin, is synthesized by this enzyme, potentially impacting neurological health.

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