Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of tumor-specific CD8+ T cells prior to radiopharmaceutical therapy improves antitumor response.

Journal for immunotherapy of cancer·2026
Same author

Radiopharmaceutical therapy provides superior survival advantage for leptomeningeal metastasis compared to external beam radiotherapy.

Neuro-oncology·2026
Same author

Preclinical Evaluation of Radium-223 and Immune Checkpoint Inhibitors Using an Immune-Competent Model of Prostate Cancer Bone Metastases.

Precision oncology·2026
Same author

Radionuclide-Dependent Stimulation of Antitumor Immunity in GD2-Targeted Radiopharmaceutical Therapy Combined with Immune Checkpoint Inhibitors.

Radiation (Multidisciplinary Digital Publishing Institute)·2026
Same author

Enhanced Response to Radiopharmaceutical Therapy in Preclinical Tumor Models with XRD-0394, a Dual Inhibitor of ATM Kinase and DNA-PKcs.

Radiation research·2026
Same author

Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice.

Nature communications·2026
Same journal

An accessible, absorbance-based plate reader assay to assess cumulative exposure of blood plasma & serum to thawed conditions.

Methods (San Diego, Calif.)·2026
Same journal

EC-isHCR: A rapid method for in situ hybridization chain reaction in diverse animal samples.

Methods (San Diego, Calif.)·2026
Same journal

Single-Molecule methods to investigate mechanisms of transcription by RNA polymerase of Mycobacterium tuberculosis.

Methods (San Diego, Calif.)·2026
Same journal

Detection and sequencing of Usutu virus during mosquito surveillance: Use of multiple assays and techniques for identification at low levels.

Methods (San Diego, Calif.)·2026
Same journal

Experimental validation of an AI-driven digital healthcare platform for oral health behavior and plaque assessment among vietnamese children.

Methods (San Diego, Calif.)·2026
Same journal

Zeta potential: An efficient and cost-effective alternative for investigating cell-surface interactions.

Methods (San Diego, Calif.)·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

Small animal micro-CT colonography.

Benjamin Y Durkee1, Jamey P Weichert, Richard B Halberg

  • 1Department of Medical Physics, University of Wisconsin-Madison, United States.

Methods (San Diego, Calif.)
|August 5, 2009
PubMed
Summary
This summary is machine-generated.

Microcomputed tomography colonography (mCTC) enables precise detection and volume estimation of colon tumors in mice. This non-invasive imaging method supports longitudinal studies for evaluating tumor fate and therapeutic responses.

More Related Videos

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Related Experiment Videos

Last Updated: Jun 21, 2026

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

  • Veterinary Radiology
  • Oncology Imaging
  • Preclinical Cancer Research

Background:

  • Colorectal cancer research in mice requires accurate tumor monitoring.
  • Existing imaging techniques have limitations in resolution and longitudinal tracking.

Purpose of the Study:

  • To introduce and validate microcomputed tomography colonography (mCTC) for detecting and quantifying colonic tumors in murine models.
  • To assess the precision, accuracy, and reproducibility of mCTC for tumor volume estimation.
  • To compare mCTC with other small animal imaging modalities.

Main Methods:

  • Utilizing microCT with 100-micron resolution for colonic tumor imaging in mice.
  • Optimizing scan quality through proper anesthesia, bowel cleansing, and insufflation.
  • Employing 2D and 3D rendering for tumor detection and semi-automated algorithms in Amira software for volume estimation.

Main Results:

  • mCTC accurately detects colonic tumors in murine models, applicable to various colorectal cancer models.
  • Tumor volume estimation is precise, accurate, and reproducible, detecting volume changes as small as 16%.
  • mCTC facilitates longitudinal studies, enhancing statistical power and reducing animal usage compared to cross-sectional studies.

Conclusions:

  • Microcomputed tomography colonography is a valuable non-invasive tool for preclinical colorectal cancer research.
  • mCTC allows for precise monitoring of tumor progression and therapeutic efficacy in longitudinal studies.
  • This imaging platform offers advantages over other small animal imaging techniques for colon tumor analysis.