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Updated: Jun 21, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
Published on: April 14, 2026
From osteoarthritis treatments to future regenerative therapies for cartilage
Johann Clouet1, Claire Vinatier, Christophe Merceron
1INSERM (Institut National de la Santé et de la Recherche Médicale), U791, Centre for Osteoarticular and Dental Tissue Engineering, Group Physiopathology of Skeletal Tissues and Cartilage Engineering, University of Nantes, France.
Abstract:
Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying inflammatory syndrome of the synovium in addition to alteration of the subchondral bone. The molecular and cellular events involved in OA have only partially been elucidated. This review provides a global view of the physiopathology of OA, as well as non-pharmacological and pharmacological treatments for the disorder. An update on surgical treatments and their indications is given with an orientation towards the management of OA and cartilage repair by cell-based regenerative therapies. These promising biological technologies will, potentially, play a major role in the treatment of cartilage-associated diseases.
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