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Updated: Jun 21, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Triclosan
Ana I Ramos1, Susana S Braga, Filipe A Almeida Paz
1Department of Chemistry, University of Aveiro, CICECO, 3810-193 Aveiro, Portugal.
Abstract:
The title compound [systematic name: 5-chloro-2-(2,4-dichlorophenoxy)phenol], C12H7Cl3O2, is a biologically relevant molecule with biocide activity. It crystallizes in the chiral trigonal space group P3(1) with one molecule in the asymmetric unit. As in biological adducts, the two aromatic rings are almost mutually perpendicular, with this structural feature leading to a distribution of the pendant -OH groups to maximize the formation of O-H...O hydrogen bonds. This arrangement leads to a chain of molecules running parallel to the c axis and having a C(2) graph-set motif at its core.
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