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Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Updated: Jun 21, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

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Published on: April 6, 2022

Lactoferrin in gastrointestinal disease.

Tetsuo Hayakawa1, Chun Xiang Jin, Shigeru B H Ko

  • 1Meijo Hospital, Nagoya. t_hayakawa@meijohosp.com

Internal Medicine (Tokyo, Japan)
|August 5, 2009
PubMed
Summary

Lactoferrin, an iron-binding protein, serves as a reliable biomarker for inflammation in various body fluids. Its levels indicate neutrophil activity, aiding in diagnosing gastrointestinal diseases and bacterial peritonitis.

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Published on: October 1, 2015

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Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

Area of Science:

  • Biochemistry
  • Immunology
  • Gastroenterology

Background:

  • Lactoferrin is a major whey protein found in external secretions and neutrophils.
  • Its presence in body fluids correlates with neutrophil flux, making it a potential inflammation biomarker.

Purpose of the Study:

  • To explore lactoferrin's role as a biomarker in various physiological and pathological conditions.
  • To investigate the diagnostic utility of lactoferrin in gastrointestinal and autoimmune diseases.

Main Methods:

  • Assessment of lactoferrin levels in different body fluids (feces, ascites, pancreatic juice, serum).
  • Evaluation of lactoferrin and anti-lactoferrin autoantibody as diagnostic markers.

Main Results:

  • Increased fecal lactoferrin is a sensitive marker for inflammatory bowel diseases.
  • Ascites lactoferrin shows promise for diagnosing bacterial peritonitis.
  • Lactoferrin in pancreatic secretions may offer insights into ductal stone formation.

Conclusions:

  • Lactoferrin is a valuable biomarker for inflammation and specific gastrointestinal conditions.
  • Further research is needed to fully understand the diagnostic and prognostic value of serum anti-lactoferrin autoantibodies.