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Updated: Jun 21, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophil-associated gastrointestinal disorders with asthma: immunohistochemical analyses
Toshihiro Shirai1, Akira Komiyama, Hiroshi Hayakawa
1Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka. tmjkshi@general-hosp.pref.shizuoka.jp
Abstract:
We report 5 patients with eosinophil-associated gastrointestinal disorders (EGIDs) and asthma. All patients developed EGIDs while asthma remained clinically stable. Asthma severity was moderate persistent and severe persistent and 2 patients had intolerance to nonsteroidal anti-inflammatory drugs. By immunohistochemical analysis of the mucosa, eosinophils, macrophages, and T cells were found to be the major infiltrating cells. There was a lesser degree of infiltration of mast cells and B cells but no neutrophils. Compared with normal controls, increased counts of eosinophils and CD8+ T cells were found in the duodenum, and eosinophils, macrophages, and CD4+ T cells in the colon.
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