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Related Concept Videos

Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Related Experiment Video

Updated: Jun 21, 2026

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Published on: August 4, 2011

The vulnerable patient: refocusing on the plaque?

Wouter J Eijgelaar1, Sylvia Heeneman, Mat J A P Daemen

  • 1Department of Pathology, University of Maastricht, Maastricht, The Netherlands. Wouter.Eijgelaar@PATH.unimaas.nl

Thrombosis and Haemostasis
|August 5, 2009
PubMed
Summary

Identifying vulnerable plaques is crucial for predicting cardiovascular events. Research now focuses on individual patient risk factors and plaque characteristics, moving beyond traditional population-based metrics for better event prediction.

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In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Semi-Automated Planimetric Quantification of Dental Plaque Using an Intraoral Fluorescence Camera
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Published on: January 27, 2023

Area of Science:

  • Cardiovascular Research
  • Atherosclerosis and Plaque Rupture Dynamics

Background:

  • Vulnerable plaques are lesions prone to rupture, causing acute coronary syndrome or stroke.
  • Traditional risk factors (age, BMI, hypertension) inadequately predict near-future cardiovascular events in high-risk individuals.
  • Research paradigms have shifted from population-based to individual-based risk assessment.

Purpose of the Study:

  • To review the evolution of identifying patients at risk for cardiovascular events.
  • To explore the shift from vulnerable plaque detection to vulnerable patient identification.
  • To highlight current research focusing on plaque-derived biomarkers and imaging for vulnerability assessment.

Main Methods:

  • Review of research paradigms in cardiovascular risk assessment.
  • Analysis of the transition from population-based to conditional risk factors.
  • Examination of systemic and plaque-derived biomarkers for cardiovascular event prediction.

Main Results:

  • Early research focused on traditional risk factors, which are insufficient for near-future event prediction.
  • The focus shifted to identifying the 'vulnerable patient' using systemic biomarkers.
  • Current research is refocusing on the plaque itself, seeking plaque-derived biomarkers and advanced imaging.

Conclusions:

  • Both 'vulnerable patient' and plaque-centric approaches require further validation in large cohorts.
  • Cost-effectiveness of new risk assessment strategies needs thorough evaluation.
  • Future research should integrate systemic and plaque-based assessments for comprehensive cardiovascular risk stratification.