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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Pathophysiology of burns.

Maike Keck1, David H Herndon, Lars P Kamolz

  • 1Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria. maike.keck@meduniwien.ac.at

Wiener Medizinische Wochenschrift (1946)
|August 5, 2009
PubMed
Summary

Burn injuries cause significant worldwide health problems. Understanding the pathophysiology, including local and systemic responses to burn trauma, improves patient outcomes.

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Area of Science:

  • Medical Sciences
  • Physiology
  • Trauma Care

Background:

  • Burn injury is a major global health concern.
  • Therapeutic strategies have advanced due to improved understanding of burn pathophysiology.
  • Clinical outcomes for burn patients have improved over recent years.

Purpose of the Study:

  • To describe the current understanding of burn injury pathophysiology.
  • To detail both local and systemic responses to burn trauma.
  • To focus on organ and systemic effects from hypovolemia and mediators.

Main Methods:

  • Literature review of current research on burn injury pathophysiology.
  • Synthesis of information on local and systemic responses.
  • Analysis of the impact of hypovolemia and circulating mediators.

Main Results:

  • Burn injuries elicit complex local and systemic pathophysiologic responses.
  • Hypovolemia and circulating mediators significantly impact organ systems.
  • Understanding these responses is key to improving patient management.

Conclusions:

  • A comprehensive understanding of burn pathophysiology is crucial for effective treatment.
  • Further research into the mechanisms of systemic effects can lead to better therapeutic interventions.
  • Advances in understanding pathophysiology directly correlate with improved clinical outcomes in burn care.