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Related Experiment Video

Updated: Jun 21, 2026

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

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Published on: February 7, 2020

Modafinil as a potential motion sickness countermeasure.

Robert E Hoyt¹, Benton D Lawson, Heather A McGee

¹Naval Aerospace Medical Research Laboratory, Pensacola, FL, USA. Robert.Hoyt@med.navy.mil

Aviation, Space, and Environmental Medicine

|August 6, 2009

Summary

Modafinil alone did not effectively treat motion sickness. However, the combination of modafinil and scopolamine showed potential for improved efficacy in preventing motion sickness symptoms.

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Area of Science:

Neuroscience
Pharmacology
Military Medicine

Background:

Motion sickness significantly impacts military operations.
Current medications for motion sickness have side effects.
Novel treatments are needed to mitigate motion sickness.

Purpose of the Study:

To evaluate the anti-motion sickness efficacy of modafinil, alone and in combination with scopolamine.
To assess modafinil as a potential alternative to dextroamphetamine for motion sickness treatment.

Main Methods:

A double-blind, placebo-controlled study involving 60 participants.
Induced moderate nausea using a Coriolis cross-coupling stimulus.
Compared three conditions: placebo, modafinil alone, and modafinil with scopolamine.

Main Results:

The combination of modafinil and scopolamine significantly increased head tilts tolerated compared to placebo.
Modafinil administered alone did not show significant improvement over placebo.
No cognitive performance decrements were observed in any group.

Conclusions:

Modafinil monotherapy was not effective for motion sickness.
The modafinil-scopolamine combination warrants further investigation for efficacy and side effect profile compared to scopolamine alone.