Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CHARACTERIZING INTRAOCULAR LENS POSITION, STABILITY, AND IRIS MOBILITY IN EYES THAT HAVE UNDERGONE SUTURELESS INTRASCLERAL HAPTIC FIXATION.

Retina (Philadelphia, Pa.)·2026

Same author

Bilateral Peripheral Neovascularization in Hemoglobin C Trait Retinopathy.

Journal of vitreoretinal diseases·2026

Same author

Management and Surgical Outcomes of Tractional Retinal Detachment Associated With Ocular Syphilis.

Ophthalmic surgery, lasers & imaging retina·2025

Same author

MULTIMODAL IMAGING AND LONG-TERM TREATMENT OUTCOMES OF RELENTLESS PLACOID CHORIORETINITIS.

Retina (Philadelphia, Pa.)·2025

Same author

Comorbid Depression and Anxiety Risk in Older Individuals with Geographic Atrophy: A US Claims Data Analysis.

Advances in therapy·2025

Same author

Vitamin A is necessary for acquisition, but not for expression or progression, of CNS autoimmunity.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Primary intraocular lymphoma.

Lisa J Faia¹, Chi-Chao Chan

¹Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

Archives of Pathology & Laboratory Medicine

|August 6, 2009

Summary

This summary is machine-generated.

Primary intraocular lymphoma, a type of central nervous system lymphoma, often progresses to the brain. Diagnosis requires tissue analysis, and while treatments exist, the relapse rate for this aggressive lymphoma remains high.

More Related Videos

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Ophthalmology
Neurology
Oncology

Background:

Primary intraocular lymphoma (PIOL), a subset of primary central nervous system lymphoma, is typically an aggressive diffuse large B-cell lymphoma.
A significant percentage of PIOL patients (56-85%) develop cerebral lesions, highlighting its systemic implications.
Patients often present with decreased vision and floaters due to chronic vitritis and subretinal lesions.

Purpose of the Study:

To summarize the characteristics, diagnostic challenges, and treatment outcomes of primary intraocular lymphoma.
To emphasize the link between ocular and central nervous system involvement in this malignancy.

Main Methods:

Review of existing literature on primary intraocular lymphoma.
Analysis of diagnostic criteria, including histopathology and ancillary tests like flow cytometry and gene rearrangement studies.
Discussion of current therapeutic strategies and their efficacy.

Main Results:

Primary intraocular lymphoma frequently metastasizes to the brain.
Diagnosis is challenging, necessitating tissue biopsy for confirmation.
Atypical lymphoid cells exhibit specific morphological features.
Ancillary tests such as flow cytometry and immunohistochemistry are crucial for accurate diagnosis.
Despite treatment with chemotherapy and radiation, relapse rates remain high.

Conclusions:

Primary intraocular lymphoma is an aggressive malignancy with a high risk of central nervous system involvement.
Accurate and timely diagnosis is critical for effective management.
Current treatment modalities offer limited long-term success, with a persistent high rate of relapse.