Arteriosclerosis: rethinking the current classification

Gregory A Fishbein1, Michael C Fishbein

  • 1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. mfishbein@mednet.ucla.edu

Insights

Arteriosclerosis, a leading cause of death, has a flawed classification system. A revised system is needed to accurately categorize vascular lesions like atherosclerosis and arteriolosclerosis.

Area of Science:

  • Vascular pathology
  • Medical terminology
  • Arterial diseases

Background:

  • Arteriosclerosis is a major cause of mortality in industrialized nations.
  • Current classification includes atherosclerosis, Mönckeberg medial calcific sclerosis, and arteriolosclerosis.
  • Existing terminology for arteriosclerosis is problematic and often misused.

Purpose of the Study:

  • To review the history and current classification of arteriosclerosis.
  • To identify issues with the existing classification system.
  • To discuss newly identified arterial lesions not currently classified.

Main Methods:

  • Review of existing literature on arteriosclerosis classification.
  • Analysis of the current classification's naming conventions and accuracy.
  • Identification of omissions in the current classification.

Main Results:

  • The current arteriosclerosis classification has inconsistent naming.
  • Terms used do not always accurately describe the lesions.
  • Important arterial lesions are missing from the current classification.
  • Arteriosclerosis and atherosclerosis are frequently used interchangeably despite distinct meanings.

Conclusions:

  • A new, more inclusive classification of arteriosclerotic lesions is needed.
  • The revised classification should accurately reflect lesion pathology.
  • Improved terminology will enhance understanding and treatment of vascular diseases.
Abstract

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