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Arteriosclerosis: rethinking the current classification
Gregory A Fishbein1, Michael C Fishbein
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. mfishbein@mednet.ucla.edu
Insights
Arteriosclerosis, a leading cause of death, has a flawed classification system. A revised system is needed to accurately categorize vascular lesions like atherosclerosis and arteriolosclerosis.
Area of Science:
- Vascular pathology
- Medical terminology
- Arterial diseases
Background:
- Arteriosclerosis is a major cause of mortality in industrialized nations.
- Current classification includes atherosclerosis, Mönckeberg medial calcific sclerosis, and arteriolosclerosis.
- Existing terminology for arteriosclerosis is problematic and often misused.
Purpose of the Study:
- To review the history and current classification of arteriosclerosis.
- To identify issues with the existing classification system.
- To discuss newly identified arterial lesions not currently classified.
Main Methods:
- Review of existing literature on arteriosclerosis classification.
- Analysis of the current classification's naming conventions and accuracy.
- Identification of omissions in the current classification.
Main Results:
- The current arteriosclerosis classification has inconsistent naming.
- Terms used do not always accurately describe the lesions.
- Important arterial lesions are missing from the current classification.
- Arteriosclerosis and atherosclerosis are frequently used interchangeably despite distinct meanings.
Conclusions:
- A new, more inclusive classification of arteriosclerotic lesions is needed.
- The revised classification should accurately reflect lesion pathology.
- Improved terminology will enhance understanding and treatment of vascular diseases.
Context:
Arteriosclerosis is the vascular disease that is the leading cause of mortality in industrialized countries. Currently, there are 3 lesions within the broader category of arteriosclerosis: atherosclerosis, Mönckeberg medial calcific sclerosis, and arteriolosclerosis.
Objective:
In this review, we discuss the history of the terminology and current classification of arteriosclerosis and problems with the current classification. We also discuss recently described new arterial lesions that are not in the current classification.
Data Sources:
In spite of the prevalence and importance of arteriosclerotic vascular disease, and the widespread use of the current terminology, there are major problems with the current classification: (1) the current classification has an inconsistent naming convention, (2) the classification fails to use terms that accurately describe the lesions, and (3) important arterial lesions are absent from the classification. In addition, although the terms arteriosclerosis and atherosclerosis describe different lesions, these terms are often used interchangeably.
Conclusion:
Consideration should be given for a new more inclusive and accurate classification of "arteriosclerotic" lesions that more accurately reflects the pathology of these important vascular lesions.
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