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Updated: Jun 21, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

Renal dysfunction in cardiac surgery: identifying potential risk factors.

J L Barnum¹, J J Sistino

¹Division of Cardiovascular Perfusion, College of Health Professions, Medical University of South Carolina, Charleston, SC 29425, USA.

|August 6, 2009

Summary

This study found that aprotinin use in cardiac surgery at MUSC was not associated with increased renal failure or mortality, contrary to previous findings. Patients at MUSC showed lower rates of dialysis and death, despite higher risk factors for kidney issues.

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Last Updated: Jun 21, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

Area of Science:

Cardiovascular Surgery
Nephrology
Pharmacology

Background:

Aprotinin use in cardiac surgery has been linked to increased renal failure and mortality.
Previous studies suggest aprotinin poses significant risks to kidney function and patient survival post-cardiac procedures.

Purpose of the Study:

To compare renal failure and mortality rates in cardiac surgery patients at MUSC with previously published data.
To evaluate the association between aprotinin use and adverse renal outcomes, considering patient risk factors.

Main Methods:

Retrospective study of 2292 cardiac surgery patients (Jan 2004-June 2008), excluding 49 on preoperative dialysis.
Patients categorized into groups: aprotinin (n=436), tranexamic acid (n=61), and off-pump coronary artery bypass (OPCAB) (n=219).
Outcomes assessed: post-operative renal dialysis and mortality. Risk factors compared to Mangano et al. (2006) NEJM study.

Main Results:

No significant difference in risk factors (diabetes, hypertension, creatinine >1.3 mg/dl, low ejection fraction) between aprotinin and control groups.
MUSC patients exhibited lower rates of renal dialysis and mortality compared to published data.
Despite higher overall risk factors for renal failure, MUSC patients showed a lower incidence of preoperative serum creatinine >1.3 mg/dl (8.3% vs. 15.1%).

Conclusions:

The use of aprotinin at MUSC was not associated with increased renal failure or mortality in this patient cohort.
Findings suggest that the risks associated with aprotinin may be population-specific or influenced by other factors.
Further research is warranted to elucidate the discrepancies in aprotinin-associated renal risks across different healthcare settings.