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Updated: Jun 21, 2026
09:31
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Brain amyloidoma with cerebral hemorrhage
Henrick Labro1, Zaid Al-Kadhimi, Mounir Djmil
1Department of Medicine and Neurological Institute at St John West Shore Hospital, University Hospitals Case Medical Center in Cleveland, Ohio 44145, USA. henrick.labro@csauh.com
The Journal of the American Osteopathic Association
|August 6, 2009
Summary
Diagnosing primary brain amyloidoma is difficult without systemic signs. This case highlights lambda-positive protein deposition in the brain, presenting unique diagnostic challenges and varied neurological symptoms.
Area of Science:
- Neurology
- Pathology
Background:
- Primary brain amyloidoma is rare and difficult to diagnose without systemic involvement.
- Advanced neuroimaging alone is often insufficient for definitive diagnosis.
Observation:
- A 64-year-old woman presented with frontal lobe syndrome and abnormal linear enhancement on MRI.
- Stereotactic biopsy revealed lambda-positive protein deposition in the brain parenchyma.
- The patient later experienced acute cerebral hemorrhage with neurological deficits.
Findings:
- The case demonstrates lambda-positive protein deposition as a key finding in primary brain amyloidoma.
- Literature review identified 15 similar cases with diverse presentations due to varied lesion locations.
- Brain amyloidomas can lead to significant neurological symptoms, including hemorrhage.
Implications:
- This case underscores the diagnostic challenges of primary brain amyloidoma.
- Early recognition and biopsy are crucial for accurate diagnosis and management.
- Further research is needed to understand the pathogenesis and improve diagnostic strategies for brain amyloidoma.
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