Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Anti-inflammatory Annexin A1 in Periodontitis via Formyl Peptide Receptor 2.

Journal of dental research·2025

Same author

[Clinical analysis of fertility-sparing therapy of patients with complex atypical hyperplasia and endometrial cancer].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2022

Same author

Clinical impacts of sun exposures on the faces and hands of Japanese women of different ages.

International journal of cosmetic science·2019

Same author

Hypoxia-inducible factor-1α inhibits interleukin-6 and -8 production in gingival epithelial cells during hypoxia.

Journal of periodontal research·2016

Same author

Deep venous thrombosis was not detected after total knee arthroplasty in Japanese patients with haemophilia.

Haemophilia : the official journal of the World Federation of Hemophilia·2015

Same author

Images created in a model eye during simulated cataract surgery can be the basis for images perceived by patients during cataract surgery.

Eye (London, England)·2014

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Spheroid Assay to Measure TGF-β-induced Invasion

Spheroid Assay to Measure TGF-β-induced Invasion

Published on: November 16, 2011

CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion.

P A Havre¹, M Abe, Y Urasaki

¹Division of Hematology/Oncology, University of Florida, Gainesville, FL 32610, USA.

British Journal of Cancer

|August 6, 2009

Summary

CD26 expression in T cells enhances invasion mediated by SDF-1-alpha, a process involving PI-3K and MEK1 pathways. CD45 may also play a role in CD26-driven cell invasion.

More Related Videos

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Published on: May 1, 2015

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Related Experiment Videos

Last Updated: Jun 21, 2026

Spheroid Assay to Measure TGF-β-induced Invasion

Spheroid Assay to Measure TGF-β-induced Invasion

Published on: November 16, 2011

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Published on: May 1, 2015

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

CD26 is a glycoprotein involved in tumor growth.
CD26 expression correlates with aggressiveness in T-cell malignancies.

Purpose of the Study:

Investigate the role of CD26 in T-cell invasiveness.
Determine the molecular pathways regulating CD26-mediated invasion.

Main Methods:

In vitro invasion assays using T-cell lines with varying CD26 expression.
Flow cytometry and western immunoblotting for protein analysis.
Zymography to assess enzyme activity and inhibitor effects.

Main Results:

CD26 expression enhanced SDF-1-alpha-mediated T-cell invasion.
PI-3K and MEK1 pathways regulate invasion via Akt and p44/42 MAP kinase phosphorylation.
CD45 inhibition reduced CD26-associated invasion.

Conclusions:

CD26 upregulates SDF-1-alpha-induced invasion in T cells through PI-3K and MEK1 pathways.
CD45 may mediate CD26's role in invasion, requiring further investigation.