Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated epidemiologic investigation and genomic confirmation of a Klebsiella pneumoniae neonatal sepsis outbreak in Botswana.

PLOS global public health·2026
Same author

Subretinal Aspects of the Optoretinographic Response.

Investigative ophthalmology & visual science·2026
Same author

Modulation of Systemic Osmolarity Alters Retinal Thickness and Schisis Cavities Without Blood Retinal Barrier Disruption in Rs1 Knockout Mice.

Investigative ophthalmology & visual science·2026
Same author

Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.

Biomedical optics express·2026
Same author

Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data.

PLoS medicine·2026
Same author

Dark adaptation of cone photoreceptor responses is revealed by optoretinography.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 21, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Error budget analysis for an adaptive optics optical coherence tomography system.

Julia W Evans1, Robert J Zawadzki, Steven M Jones

  • 1Department of Ophthalmology & Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California, Davis, Sacramento, CA 95817, USA. evans74@llnl.gov

Optics Express
|August 6, 2009
PubMed
Summary

Adaptive optics optical coherence tomography (AO-OCT) enhances retinal imaging resolution. An error budget identified bandwidth and controller errors as key limitations, guiding future AO-OCT system improvements for better cellular-level eye imaging.

More Related Videos

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Related Experiment Videos

Last Updated: Jun 21, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optical Physics

Background:

  • Adaptive optics (AO) combined with optical coherence tomography (OCT) provides cellular-level retinal imaging.
  • Current AO-OCT systems achieve micrometer resolution but struggle with imaging certain cell types.
  • Enhanced contrast, not just resolution, is crucial for further advancements.

Purpose of the Study:

  • To develop an error budget for the UC Davis AO-OCT instrument.
  • To identify the primary sources limiting AO-OCT system performance.
  • To guide future improvements for enhanced retinal imaging.

Main Methods:

  • Development of a detailed error budget for the AO-OCT system.
  • Analysis of constituent residual errors impacting optical performance.
  • Assessment of error source scaling across different subjects.

Main Results:

  • Bandwidth and controller errors were identified as the main limitations in the UC Davis AO-OCT system.
  • These errors significantly impact the system's ability to achieve optimal performance.
  • Subject variability presents challenges for system robustness.

Conclusions:

  • Prioritizing correction of bandwidth and controller errors will yield the most significant AO-OCT performance improvements.
  • Addressing subject variability is essential for developing a more robust AO-OCT system.
  • This error budget provides a roadmap for optimizing AO-OCT for clinical and research applications.