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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...
Diamagnetic Shielding of Nuclei: Local Diamagnetic Current01:14

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

An applied magnetic field causes the electrons present in the molecule to circulate, setting up a local diamagnetic current within the molecule. The local diamagnetic current arising from circulating sigma-bonding electrons induces a magnetic field, Blocal that opposes the applied magnetic field, B0. The effective magnetic field experienced by these nuclei is given by the difference between the applied and local magnetic fields in a phenomenon called local diamagnetic shielding. Essentially,...

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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

The novel synchronous ion shield mass analyzer.

J-P Hauschild1, E Wapelhorst, J Müller

  • 1Hamburg University of Technology, Institute of Microsystems Technology, Eissendorfer Strasse 42, 21073 Hamburg, Germany. jp.hauschild@tu-harburg.de

Journal of Mass Spectrometry : JMS
|August 6, 2009
PubMed
Summary
This summary is machine-generated.

A novel synchronous ion shield (SIS) mass analyzer allows for mass spectrometer chip fabrication using micro-electro-mechanical systems (MEMS) technology. This breakthrough enables simultaneous production of 100 miniaturized spectrometers on a single substrate.

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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer (SMPS-ICPMS)
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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer (SMPS-ICPMS)

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Area of Science:

  • Analytical Chemistry
  • Micro-Electro-Mechanical Systems (MEMS)

Background:

  • Microfabrication techniques present limitations for traditional mass spectrometer designs.
  • Miniaturization of analytical instrumentation is a key goal in modern science.

Purpose of the Study:

  • To introduce a novel synchronous ion shield (SIS) mass analyzer.
  • To address fabrication constraints in micro-electro-mechanical systems (MEMS) for mass spectrometry.

Main Methods:

  • Design and simulation of the SIS mass analyzer and associated ion optics.
  • Integration of an energy filter for enhanced performance.
  • Experimental validation of the fabricated mass spectrometer chip.

Main Results:

  • Demonstration of mass spectrometer chip fabrication using MEMS technology.
  • Simultaneous production of 100 SIS mass analyzer chips (7.10 mm²) on a 100 mm substrate.
  • Experimental data confirming the feasibility and performance of the device.

Conclusions:

  • The SIS mass analyzer is a viable concept for on-chip mass spectrometry.
  • MEMS technology can be leveraged for mass spectrometer fabrication, overcoming previous limitations.
  • The developed device shows promise for portable and integrated analytical systems.