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Updated: Aug 19, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Experience with hormone receptors in renal cancer

I Romics1, C Rüssel, D Bach

  • 1Department of Urology, St. Agnes Hospital, Bocholt, FRG.

International Urology and Nephrology
|January 1, 1990
PubMed

Insights

Medroxyprogesterone acetate (MPA) therapy may not be effective for renal carcinoma. Hormone receptor analysis in 20 patients showed low or undetectable levels, questioning MPA

Area of Science:

  • Oncology
  • Endocrinology
  • Urology

Background:

  • Renal carcinoma treatment often involves hormonal therapies.
  • Medroxyprogesterone acetate (MPA) is a progestin used in some cancer treatments.
  • The efficacy of MPA may depend on the presence of specific hormone receptors in tumor tissue.

Purpose of the Study:

  • To determine hormone receptor concentrations in renal carcinoma tissues.
  • To evaluate the potential role of MPA in renal tumor treatment.
  • To assess if MPA has therapeutic value independent of specific receptor binding.

Main Methods:

  • Analysis of hormone receptor concentrations (estrogen, progesterone, androgen, glucocorticoid) in tumor samples from 20 renal carcinoma patients.
  • Samples were collected prior to any medroxyprogesterone acetate (MPA) therapy.

Main Results:

  • Hormone receptor concentrations were largely undetectable or extremely low in the analyzed renal carcinoma tissues.
  • Glucocorticoid receptors were the exception, with measurable concentrations.
  • None of the patients included in the receptor analysis had yet received MPA treatment.

Conclusions:

  • The absence of significant hormone receptor expression in most renal tumors suggests limited direct efficacy of MPA.
  • The therapeutic utility of MPA as a general roborant in renal carcinoma warrants further investigation.
  • Further studies are needed to clarify the role of MPA in renal cell carcinoma management.

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