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[Electropherotypes of rotavirus in children with and without gastroenteritis]
C Costa1, J A Candeias, E L Capeletti
1Departamento de Ciências da Saúde do Instituto Nacional de Pesquisas da Amazônia, Manaus, Brasil.
Insights
Human rotavirus was identified in infants with diarrhea, with the "long" electropherotype being more common. This finding aids in understanding rotavirus strains in young children.
Area of Science:
- Virology
- Pediatrics
- Molecular Epidemiology
Context:
- Diarrheal diseases are a major cause of infant mortality globally.
- Rotavirus is a primary pathogen responsible for severe gastroenteritis in children under five.
- Understanding rotavirus strains and their prevalence is crucial for developing effective interventions.
Purpose:
- To determine the prevalence of human rotavirus in infants with diarrhea.
- To characterize the electropherotypes of rotavirus strains detected in stool samples.
- To compare rotavirus prevalence and electropherotype distribution between children with and without diarrhea.
Summary:
- A study analyzed stool samples from 500 infants (0-12 months) with diarrhea (case group) and 500 healthy infants (control group).
- Human rotavirus was detected in 14.8% of the diarrhea cases, with 5 exhibiting the 'short' and 11 the 'long' electropherotype.
- In the control group, rotavirus was found in 0.8% of infants, with all three positive samples showing the 'long' electropherotype.
Impact:
- Identifies the 'long' electropherotype as a potentially significant rotavirus strain in infants with diarrhea.
- Provides epidemiological data on rotavirus prevalence and strain diversity in a young pediatric population.
- Contributes to the knowledge base for rotavirus surveillance and the development of targeted prevention strategies.
Abstract:
It was defined the electropherotypes of rotavirus identified in stools of a groups (named "case") of 500 children with diarrhea, ranging in age from 0 to 12 months. A group (named "control") of 500 children of the same age group, without diarrhea or respiratory infections, were evaluated. Human rotavirus was detected in 14.8% of the children with diarrhea. Of the positive samples 5 had the "short" and 11 the "long" electropherotype. In the control group rotavirus was detected in 0.8% of children and all the three positive samples had "long" electropherotype.