Related Experiment Video
Updated: Jun 21, 2026

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
Published on: October 26, 2016
Hydrodynamic effects on the translocation rate of a polymer through a pore
Juan P Hernández-Ortiz1, Manan Chopra, Stephanie Geier
1Departamento de Materiales, Universidad Nacional de Colombia, Sede Medellín, Kra 80 No. 65-223, Bloque M3-050 Medellín, Colombia. jphernandezo@unalmed.edu.co
Abstract:
The translocation of large DNA molecules through narrow pores has been examined in the context of multiscale simulations that include a full coupling of fluctuating hydrodynamic interactions, boundary effects, and molecular conformation. The actual rate constants for this process are determined for the first time, and it is shown that hydrodynamic interactions can lead to translocation rates that vary by multiple orders of magnitude when molecular weights are only changed by a factor of 10, in stark contrast to predictions from widely used free draining calculations.
Related Concept Videos
Protein Diffusion in the Membrane
Pore Transport and Ion-Pair Transport
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Diffusion
Diffusion
Drug Absorption Mechanism: Passive Membrane Transport
Passive Diffusion: Overview and Kinetics
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

