Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter Clinical Comparison of the 10-Minute AMDI Fast PCR Mini Respiratory Panel and the Cepheid Xpert Xpress CoV-2/Flu/RSV plus.

The Journal of molecular diagnostics : JMD·2026
Same author

Residue-specific early-stage aggregation dynamics of α-synuclein (61-95) in monolayers: A pMAIRS and AFM study.

Biophysical chemistry·2026
Same author

RHOXF1/TSGA10 axis: a possible molecular mechanism of carcinogenesis.

Cancer treatment and research communications·2026
Same author

Mechanically strong and highly conductive graphitized carbon nanowire arrays for nano-fabrication of carbon-based chips.

Microsystems & nanoengineering·2026
Same author

Carbon-dot growth on nanoconvex carbon wires for outstanding optical properties.

Materials horizons·2025
Same author

2D Composite Materials for Electrodes in Dye-Sensitized Solar Cells─An Overview.

ACS applied materials & interfaces·2025
Same journal

Fiber-optic triggering of a two-stage high-current linear transformer driver with laser energy below 100 μJ.

The Review of scientific instruments·2026
Same journal

Optimization of laboratory-scale x-ray absorption spectroscopy (XAS) apparatus for nuclear fuel research.

The Review of scientific instruments·2026
Same journal

Compressed multi-scale entropy and its application in mechanical fault diagnosis.

The Review of scientific instruments·2026
Same journal

Bidirectional drive and multi-resolution adjustment across frequency bands in inertial impact piezoelectric motors via multimodal resonant vibration.

The Review of scientific instruments·2026
Same journal

A magnetic field sensor based on flaky Terfenol-D material and dual fiber grating.

The Review of scientific instruments·2026
Same journal

A novel E-field eight-way cavity combiner for high-power S-band applications.

The Review of scientific instruments·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Reciprocating flow-based centrifugal microfluidics mixer.

Zahra Noroozi1, Horacio Kido, Miodrag Micic

  • 1Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, California 92697-3975, USA.

The Review of Scientific Instruments
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

This study presents a novel centrifugal microfluidic device for rapid, efficient fluid mixing in the nanoliter to microliter range. The device achieves quantitative mixing in under three minutes, addressing a key challenge in small-scale analytical applications.

More Related Videos

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels
08:32

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels

Published on: January 28, 2022

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Related Experiment Videos

Last Updated: Jun 21, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels
08:32

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels

Published on: January 28, 2022

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Biotechnology

Background:

  • Efficient fluid mixing is crucial for chemical reactions, especially at small scales where reagent scarcity demands high utilization.
  • Current methods for nanoliter/microliter fluid mixing are often inefficient or expensive, posing a challenge for analytical applications.

Purpose of the Study:

  • To design and fabricate a novel, inexpensive centrifugal force-based microfluidic device for fast and quantitative fluid mixing.
  • To demonstrate the device's capability for mixing fluids in the nanoliter to microliter volume range.
  • To integrate this mixing unit into broader microfluidic systems for sample preparation.

Main Methods:

  • Fabrication of a polydimethylsiloxane (PDMS) microfluidic chip bonded to a glass slide using SU-8 master molds and photolithography.
  • Utilizing centrifugal force and pneumatic pressure within a network of microchannels to achieve fluid reciprocation and mixing.
  • Monitoring mixing efficiency using planar laser-induced fluorescence (PLIF) and analyzing fluorescent intensity distributions and histograms.

Main Results:

  • Quantitative mixing of fluids (red fluorescent particles and water) was achieved in less than 3 minutes.
  • The device effectively utilizes centrifugal force and pneumatic pressure for rapid fluid manipulation.
  • High-resolution imaging and fluorescence analysis confirmed the mixing process and quantified its efficiency.

Conclusions:

  • The developed centrifugal microfluidic device offers a fast, efficient, and potentially inexpensive solution for fluid mixing at the microscale.
  • This technology can be used as a standalone unit or integrated into lab-on-a-disk systems for various analytical and sample preparation tasks.
  • The device addresses the critical need for efficient reagent utilization in small-volume analytical chemistry.