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Controlled release antibiotics for dry powder lung delivery
Handoko Adi1, Paul Michael Young, Hak-Kim Chan
1Advanced Drug Delivery Group, Faculty of Pharmacy-A15, University of Sydney, Sydney, NSW, Australia.
Drug Development and Industrial Pharmacy
|August 7, 2009
Summary
Controlled release (CR) antibiotics formulated into microparticles using polyvinyl alcohol (PVA) via spray drying demonstrated sustained drug release for pulmonary infection treatment.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Pulmonary Medicine
Background:
- Inhalation therapy offers a direct route for treating pulmonary infections.
- Controlled release (CR) antibiotic formulations are being developed for improved therapeutic outcomes.
Purpose of the Study:
- To evaluate CR antibiotic microparticles for inhalation therapy.
- To characterize ciprofloxacin and doxycycline microparticles produced by spray drying.
Main Methods:
- Spray drying was used to create microparticles with polyvinyl alcohol (PVA) and antibiotics.
- Evaluated microparticle characteristics: size, morphology, thermal properties, aerosol performance, and in vitro release.
Main Results:
- Microparticles exhibited comparable size distributions (around 2 μm).
- Aerosol performance varied for individual antibiotics but was identical for combined formulations.
- CR microparticles showed sustained release (≤50% over 6 hours) compared to rapid release without PVA.
Conclusions:
- Spray-dried PVA-based microparticles are suitable for CR antibiotic inhalation therapy.
- This approach shows promise for treating pulmonary infections effectively.
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