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Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
Published on: December 22, 2015
Bone microbial contamination influences autogenous grafting in sinus augmentation.
Fernando Verdugo1, Ana Castillo, María D Moragues
1Private practice, Huntington Beach, CA, USA. fverdugo@perio.org
Journal of Periodontology
|August 7, 2009
Summary
Periodontal pathogens were found in 83% of bone samples during maxillary sinus augmentation. This microbial contamination was linked to significant bone volume loss six months after the procedure.
Area of Science:
- Oral surgery
- Periodontology
- Regenerative medicine
Background:
- Oral microbial pathogens are present in health and disease.
- Periodontopathogens may negatively impact bone regeneration.
- Maxillary sinus augmentation is a common procedure for bone grafting.
Purpose of the Study:
- To confirm the presence of periodontal pathogens in bone particles used for maxillary sinus augmentation.
- To assess the clinical and radiographic outcomes of bone augmentation in patients with a history of periodontal disease.
Main Methods:
- Paper-point sampling of intraorally harvested bone particles.
- Culture and polymerase chain reaction (PCR) for pathogen identification.
- Radiographic assessment of bone healing and volume gain at baseline and 6-12 months post-augmentation.
Main Results:
- Periodontal pathogens identified in 83% of patients (10/12).
- Pathogen presence associated with greater bone volume loss at 6 months.
- Specific pathogens (P. gingivalis, A. actinomycetemcomitans, P. intermedia) linked to pronounced volume loss.
Conclusions:
- First study confirming osseous microbial contamination with periodontopathogens during maxillary sinus augmentation.
- Microbial contamination negatively impacts bone grafting outcomes, causing bone volume loss.
- Specific microbial contamination may impede osteogenesis in bone regeneration.
