Related Experiment Video
Updated: Jun 21, 2026

Intracameral Injection in Rats with Low Risk of Adverse Effects
Published on: May 31, 2024
The relationship of intranasal steroids to intraocular pressure
Joseph Bergmann1, Matthew T Witmer, Charles B Slonim
1Department of Ophthalmology, University of South Florida College of Medicine, Tampa, FL 33613, USA. chuck@slonim.us
Abstract:
Intranasal corticosteroids have become a gold standard in therapy for allergic rhinoconjunctivitis. A direct relationship between topical and systemic corticosteroids and elevated intraocular pressure (IOP) has been recognized for more than 50 years. However, this steroid-induced response is highly variable. Glaucoma is an eye disease caused by an increase in IOP and results in optic nerve cell death and vision loss. Intranasal corticosteroids are absorbed systemically albeit in small measurable amounts. Some studies suggest a relationship between intranasal steroids and increased IOP. Large prospective studies to determine if there is a significant relationship between intranasal steroids and increased IOP are lacking. We review the current knowledge base regarding intranasal steroid usage and steroid-induced glaucoma.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Ophthalmic Drug Delivery Systems
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
