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Updated: Jun 21, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways
Tracey A Rouault1, Wing-Hang Tong
1Molecular Medicine Program, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. trou@helix.nih.gov
Abstract:
A large-scale computational and genetic analysis study by Nilsson et al. (2009) has identified five genes that coexpress with heme biosynthetic enzymes and are required for normal heme synthesis. Several are implicated in iron-sulfur cluster biogenesis, and malfunction of these genes may repress heme synthesis by activating the IRE/IRP posttranscriptional regulatory system.
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