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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Published on: November 19, 2012

A phase code for memory could arise from circuit mechanisms in entorhinal cortex.

Michael E Hasselmo1, Mark P Brandon, Motoharu Yoshida

  • 1Center for Memory and Brain, Department of Psychology and Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA. hasselmo@bu.edu

Neural Networks : the Official Journal of the International Neural Network Society
|August 7, 2009
PubMed
Summary
This summary is machine-generated.

Entorhinal cortical neurons may encode memory through their firing phase. This mechanism could explain grid cell activity and neural replay during rest and sleep.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Entorhinal cortex (EC) neurons play a crucial role in memory formation and spatial navigation.
  • Intrinsic cellular properties of neurons are fundamental to understanding neural coding.

Purpose of the Study:

  • To explore how intrinsic cellular properties of entorhinal cortical neurons facilitate memory coding via firing phase.
  • To review potential cellular mechanisms for phase coding in computational models of entorhinal function.

Main Methods:

  • Review of neurophysiological data and computational models of entorhinal cortex function.
  • Analysis of cellular mechanisms underlying neural firing phase.
  • Discussion of implications for modeling grid cell responses and neural replay.

Main Results:

  • Intrinsic cellular properties suggest a mechanism for entorhinal cortical neurons to code memory by firing phase.
  • Phase coding provides a basis for modeling entorhinal grid cell responses.
  • This mechanism supports modeling of neural spiking activity replay during waking and sleep.

Conclusions:

  • Phase coding by entorhinal cortical neurons offers a plausible mechanism for memory representation.
  • Further research in biophysical simulations and large-scale population models is warranted to explore inhibition's role.