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Updated: Aug 3, 2026
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Psychic changes in systemic lupus erythematosus: a multidisciplinary prospective study]
E C Miguel Filho1, R M Pereira, G Busatto Filho
1Inst. de Psiquiat, Hosp. das Clín, Fac. de Med, Univ. de São Paulo HC-FMUSP.
AMB : Revista Da Associacao Medica Brasileira
|April 1, 1990
Summary
Systemic lupus erythematosus (SLE) patients frequently experience psychic symptoms, often presenting as organic mental syndromes with cognitive and affective features. This study highlights the neurological and laboratory correlates of these neuropsychiatric manifestations in lupus.
Area of Science:
- Neurology
- Psychiatry
- Immunology
Context:
- Psychic symptoms are common in lupus patients but understudied.
- Systemic lupus erythematosus (SLE) involves complex neurological and psychiatric manifestations.
- Understanding these manifestations is crucial for patient care.
Purpose:
- To characterize psychopathological aspects in SLE patients.
- To correlate psychic symptoms with clinical, neurological, and laboratory findings.
- To investigate the nervous system involvement in SLE.
Summary:
- Twelve of 23 SLE patients exhibited primary psychic alterations, mainly organic mental syndromes with prominent cognitive deficits.
- Neurologic (seizures, migraine) and ophthalmologic findings were common and concurrent with psychic symptoms.
- Specific autoantibodies (antigangliosides) and cerebrospinal fluid abnormalities were frequently observed.
Impact:
- This multidisciplinary study enhances the characterization of neuropsychiatric involvement in SLE.
- Findings suggest a significant link between autoimmune processes and mental health in lupus.
- Further research is needed to confirm these associations in larger cohorts.
